Re-bleeding events in patients with obscure gastrointestinal bleeding after negative capsule endoscopy

Table 3 Univariate and Multivariate analysis via Cox proportional hazard regression model: Re-bleeding risk factors in patients with obscure gastrointestinal bleeding and a negative capsule endoscopy

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	P	HR	95%CI	P
Female	1.408	0.676-2.929	0.361
Age > 65 years old	3.599	1.364-9.501	0.010	2.591	0.951-7.060	0.063
Chronic kidney disease	3.498	1.265-9.671	0.016	2.252	0.749-6.770	0.148
Aortic stenosis	4.159	1.412-12.247	0.010	1.548	0.352-6.811	0.563
Prior angiodysplasia	3.637	0.851-15.457	0.081
Bleeding-related drugs	1.586	0.761-3.304	0.219
Anticoagulant use	3.903	1.542-9.875	0.004	2.699	0.705-10.330	0.147
Overt OGIB	2.104	1.011-4.380	0.047	1.986	0.933-4.231	0.075
[Hb] < 80 g/L	1.857	0.868-3.970	0.111
Transfusional (RBC) needs prior to WCE	1.122	0.919-1.370	0.257

Values are presented in mean ± SD unless stated otherwise. HR: Hazard ratio; OGIB: Obscure gastrointestinal bleeding; [Hb]: Serum hemoglobin; RBC: Red blood cells; WCE: Wireless capsule endoscopy.