Systematic review of oncological outcomes following laparoscopic vs open total mesorectal excision

Table 1 Characteristics of included trials

Ref.	Year	Country	Age (yr)	Gender (M:F)	Follow up (mo)	Rectal cancer details	Procedure
Araujo et al[32]	2003	Brazil				Lower rectal cancer with neoadjuvant chemoradiotherapy	Abdominoperineal resection
LTME			59.1	9:4	47.2
OTME			56.4	10:5	47.2
Baraga et al[33]	2007	Italy				Adenocarcinoma of the rectum suitable for resection with neoadjuvant chemoradiotherapy	Anterior resection and Abdominoperineal resection
LTME			62.8 ± 12.6	55:28	53.6
OTME			65.3 ± 10.3	64:21
Gong et al[34]	2012	China				Lower and mid rectal adenocarcinoma without neoadjuvant chemoradiotherapy	Anterior resection and Abdominoperineal resection
LTME			58.4 ± 13.6	1.3:1	21 (9-56)
OTME			59.6 ± 9.4	1.29:1
Guillou et al[35]	2005	United Kingdom				Adenocarcinoma of left colon and rectum	Anterior resection and Abdominoperineal resection
LTME			69 ± 11	44% female	3
OTME			69 ± 12	46% female	3
Jayne et al[36]	2007	United Kingdom				Adenocarcinoma of left colon and rectum	Anterior resection and Abdominoperineal resection
LTME			69 ± 11	44% female	36.5
OTME			69 ± 12	46% female	36.5
Kang et al[37]	2010	South Korea				Lower and mid rectal adenocarcinoma with neoadjuvant chemoradiotherapy	Anterior resection and Abdominoperineal resection
LTME			57.8 ± 11.1	110:60	3
OTME			59.1 ± 9.9	110:60	3
Lujan et al[38]	2009	Spain				Upper rectal adenocarcinomaMid or low rectal adenocarcinomacT3N0-2 stagePreoperative chemoradiotherapy	Anterior resection and Abdominoperineal resection
LTME			67.8 ± 12.9	62:39	32.8
OTME			66 ± 9.9	64:39	34.1
Ng et al[39]	2008	Hong Kong				Lower rectal cancer within 5 cm of the anal verge	Abdominoperineal resection
LTME			63.7 ± 11.8	31:20	90.1
OTME			63.5 ± 12.6	30:18	87.2
Ng et al[40]	2009	Hong Kong				Upper rectal adenocarcinomaPreoperative chemoradiotherapy	Anterior resection
LTME			66.5 ± 11.9	37:39	112.5
OTME			65.7 ± 12	48:29	108.8
Ng et al[41]	2013	Hong Kong				Rectal adenocarcinoma located between 5 and 12 cm from the anal verge. None of the included patient had neoadjuvant treatment	Sphincter sparing total mesorectal excision
LTME			60.2 ± 11.3	24:16	84.6
OTME			62.1 ± 12.6	22:18	92.7
Zhou et al[42]	2004	China				Low rectal adenocarcinoma Intraperitoneal and 1.5 to 8 cm from the dentate line Dukes D with local infiltration Anal sphincter sparing	Anterior resection
LTME			26-85(44)	43:46
OTME			30-81(45)	46:36	1-16

LTME: Laparoscopic total mesorectal excision; OTME: Open total mesorectal excision; M: Male; F: Female.