Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding

Table 3 Number of mucosal lesions found during video capsule endoscopy in both bleeders and controls consuming non-steroidal anti-inflammatory drugs, after stratification according to the type of non-steroidal anti-inflammatory drug consumed

Patient group	Patients	Controls	P
All patients	n = 40	n = 40
Jejunum
Grade 4 lesions	1 (SD = 2)	0.3 (SD = 0.7)	0.02
Grade 3 lesions	10.8 (SD = 4.3)	1 (SD = 0.6)	< 0.0001
Ileum
Grade 4 lesions	1.1 (SD = 1.9)	0.2 (SD = 0.3)	0.002
Grade 3 lesions	8.1 (SD = 4.8)	1.2 (SD = 2.2)	< 0.0001
Low dose aspirin users	n = 22	n = 22
Jejunum
Grade 4 lesions	0.8 (SD = 1.3)	0.2 (SD = 0.4)	0.02
Grade 3 lesions	9.9 (SD = 4.7)	0.8 (SD = 0.5)	< 0.0001
Ileum
Grade 4 lesions	0.9 (SD = 1.4)	0.1 (SD = 0.3)	0.006
Grade 3 lesions	10.3 (SD = 4.6)	1 (SD = 1.6)	< 0.0001
Non-aspirin NSAID consumers	n = 24	n = 24
Jejunum
Grade 4 lesions	1.4 (SD = 2.6)	0.4 (SD = 0.9)	0.04
Grade 3 lesions	11.9 (SD = 3.8)	1.2 (SD = 0.7)	< 0.0001
Ileum
Grade 4 lesions	1.6 (SD = 2.4)	0.3 (SD = 0.3)	0.02
Grade 3 lesions	7.7 (SD = 4.8)	1.4 (SD = 2.3)	< 0.0001
COX-2 NSAID consumers	n = 6	n = 6
Jejunum
Grade 4 lesions	0.3 (SD = 0.6)	0	0.27
Grade 3 lesions	5.7 (SD = 6.7)	0.4 (SD = 1.4)	0.04
Ileum
Grade 4 lesions	0.7 (SD = 1.2)	0	0.15
Grade 3 lesions	6.7 (SD = 5.7)	0.5 (SD = 0.7)	0.01

NSAIDs: Non-steroidal anti-inflammatory drugs; SD: Standard deviation; COX-2: Cyclooxygenase-2 selective inhibitors.