Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding

Table 1 Demographic and disease related characteristics of bleeders and controls

Characteristic	Patients (n = 60)	Controls (n = 60)	P
Mean age (yr)	75 (SD = 8)	74 (SD = 9)	0.26
Male gender	44 (73%)	44 (73%)	1.00
Active smoking	18 (30%)	18 (30%)	1.00
Alcohol abuse	12 (20%)	12 (20%)	1.00
BMI > 25	36 (60%)	36 (60%)	1.00
NSAIDs consumption	40 (67%)	40 (67%)	1.00
Ischaemic heart disease	20 (33%)	20 (33%)	1.00
Chronic pain	6 (10%)	22 (37%)	0.006
Diabetes melitus	11 (18%)	12 (20%)	0.82
COPD	4 (7%)	4 (7%)	1.00
Low dose aspirin use1	22 (37%)	22 (37%)	1.00
Non aspirin NSAIDs use1	24 (40%)	24 (40%)	1.00
COX-2 selective use	6 (10%)	6 (10%)	1.00
Non selective NSAIDs use	18 (30%)	18 (30%)	1.00
Clopidogrel co-administration	12 (20%)	12 (20%)	1.00
Gastric passing time (min)	41 (SD = 49)	42 (SD = 57)	0.46
Small bowel passing time (min)	221 (SD = 117)	271 (SD = 117)	0.01
H. pylori positive	37 (60%)	37 (62%)	1.00

¹Three bleeders and 6 controls received both low-dose aspirin and non-aspirin NSAIDs. SD: Standard deviation; NSAIDs: Non-steroidal anti-inflammatory drugs; BMI: Body mass index; COPD: Chronic obstructive lung disease; COX-2 selective use: Cyclooxygenase-2 selective inhibitors.