Usefulness of applying lidocaine in esophagogastroduodenoscopy performed under sedation with propofol

Table 3 Influence of potentially confounding factors on the propofol dose (mg/kg per minute, adjusted for patient weight and examination time)

			Diff1	P2
Age, yr
	< 65	> 65
Total propofol dose	315.3 ± 118.9	223.9 ± 73.7	91.4 (49.3, 133.5)	< 0.001
Partial3 propofol dose	138.2 ± 135.5	96.0 ± 81.4	42.2 (-5.6, 90.0)	0.08
Sex
	Male	Female
Total propofol dose	263.7 ± 87.9	314.6 ± 127.9	-59.9 (-93.8, -8.0)	0.02
Partial propofol dose	111.5 ± 101.9	139.6 ± 139	-28.1 (-75.4, 19.2)	0.20
ASA classification
	I-II	III-IV
Total propofol dose	310.8 ± 121.3	239.8 ± 77.7	71.0 (21.2, 120.8)	< 0.001
Partial propofol dose	135.9 ± 136.3	104.1 ± 80.1	31.9 (-23.6, 87.4)	0.20
Mallampati classification
	I-II	III-IV
Total propofol dose	302.4 ± 119.5	262.4 ± 98.6	40.0 (-15.3, 95.3)	0.10
Partial propofol dose	127.1 ± 133.9	137.7 ± 85.9	-10.6 (-71.5, 49.9)	0.70
Drug abuse
	Yes	No
Total propofol dose	320.5 ± 92.1	293.0 ± 118.7	27.5 (-48.9, 103.9)	0.40
Partial propofol dose	120.3 ± 87.1	129.8 ± 129	-9.5 (-92.6, 73.6)	0.80
Previous sedated EGD
	Yes	No
Total propofol dose	260.2 ± 102.7	302.8 ± 118.6	-42.6 (-97.4, 12.2)	0.10
Partial propofol dose	128.9 ± 108.4	129.0 ± 130.6	-0.1 (-60.1, 59.9)	0.90

Quantitative and qualitative variables are expressed as average ± SD and as percentage with 95%CI, respectively.

¹Differences are expressed as RR with their respective absolute values; ²Values in bold are statistically significant;

³Measurements recorded from the time of endoscope insertion into the oral cavity up to the time of withdrawal, excluding the time of anaesthetic induction. ASA: American Society of Anaesthesiologists; EGD: Esophagogastroduodenoscopy.