Ultra high magnification endoscopy: Is seeing really believing?

Table 3 Confocal endomicroscopy and endocytoscopy findings of colonic architecture[33,34,36]

Feature	Normal	Malignant
Vessel Architecture	Hexagonal, honeycomb appearance of capillaries	Distorted, dilated capillaries with increased leakage
	Capillaries surround the stroma, which encircle the crypt openings	Irregular arrangement with no specific relationship to adjacent tissue
Crypts	Regular luminal openings and distribution	Heterogeneous distribution with irregular layer epithelial cells
	Crypts covered by uniform layer of epithelial cells (including Goblet cells)	Loss of crypts and goblet cells
Sensitivity		ECS: 79%-91%[6,35]
		CEM: 91%[37]
Specificity		ECS: 90%-100%[6,35]
		CEM: 76%[37]