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World J Gastrointestinal Endoscopy. Oct 16, 2011; 3(10): 183-194
Published online Oct 16, 2011. doi: 10.4253/wjge.v3.i10.183
Published online Oct 16, 2011. doi: 10.4253/wjge.v3.i10.183
Technology | Contrast | Field of view | Lateral resolution | Clinical results | |||
Trial | Patients(n) | No. of examined areas | Results | ||||
Confocal laser endoscopy (Pentax-eCLE) | IV fluorescein | 475 μm | 0.7 μm | Kiesslich et al[36] | 63 | 156 | Barrett’s: Sensitivity 98.1%; Specificity 94% |
Topical acriflavine 0.05% | Esophageal neoplasia: Sensitivty 92.9%; Specificity 98.4% | ||||||
Confocal laser endoscopy (Mauna Kea-pCLE) | IV fluorescein | 240-600 μm | 1 μm | Bajbouj et al[51] | 39 | 670 | Specificity: 97% (blinded), 95% (on-site); |
Topical acriflavine 0.05% | Sensitivity: 28% (blinded), 12% (on-site) | ||||||
Endocytoscopy (Olympus) | Absorptive contrast (i.e. Methylene Blue or Toludine Blue) | < 0.5 mm | 1.7-4 μm | Pohl et al[33] | 16 | 166 | PPV/NPV (HGIN or cancer in Barrett’s patients)-0.29/0.87 (× 450)-0.44/0.83 (× 1125) |
Sasajima et al[35] | 6 | 7 | 93.3% accuracy in colon cancer detection | ||||
HRME | Topical proflavine 0.01% | 750 μm | < 4 μm | N/A→Currently going to clinical trial | |||
Optical coherence tomography | None | Traditional systems: 7-20 μm | Poneros et al[52 | 121 | 288 | Diagnosis of intestinal metaplasia: 97% sensitive, 92% specific | |
Catheter-based: 1-2 μm |
- Citation: Shukla R, Abidi WM, Richards-Kortum R, Anandasabapathy S. Endoscopic imaging: How far are we from real-time histology? World J Gastrointestinal Endoscopy 2011; 3(10): 183-194
- URL: https://www.wjgnet.com/1948-5190/full/v3/i10/183.htm
- DOI: https://dx.doi.org/10.4253/wjge.v3.i10.183