Gastroesophageal reflux disease: Important considerations for the older patients

doi:10.4253/wjge.v2.i12.388

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Dec 16, 2010 (publication date) through Feb 8, 2025

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Dec 16, 2010; 2(12): 388-396
Published online Dec 16, 2010. doi: 10.4253/wjge.v2.i12.388

Table 3 Potential effects of prolonged acid suppression with histamine₂ receptor antagonists and PPI agents

Reduced absorption of nutrients and calcium

B₁₂, iron, calcium

Osteoporosis

Bacterial proliferation

Community acquired pneumonia

Clostridium difficile

Drug metabolism interference

Acid effects on drug absorption

PPI Effects on CYP2C19 pathway interference

Clopidogrel

Histamine₂ receptor antagonists effects on cytochrome P-450 3A4 system

Warfarin, phenytoin, benzodiazepines, theophylline

Drug side effects

Delirium, especially cimetidine

Neurorologic

Antiandrogen

Cardiac side effects

Hematologic

PPI: proton pump inhibitor.

Citation: Chait MM. Gastroesophageal reflux disease: Important considerations for the older patients. World J Gastrointest Endosc 2010; 2(12): 388-396
URL: https://www.wjgnet.com/1948-5190/full/v2/i12/388.htm
DOI: https://dx.doi.org/10.4253/wjge.v2.i12.388