Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy

Table 3 Diagnostic accuracy of routine cytology and immunohistochemistry, alone or in selected combinations, in detection of pancreatic cancer via endoscopic ultrasound-guided fine needle aspiration

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	PLR	NLR
Cytology	41	100	100	29	¥	0.59
p53 + cytology	51	100	100	33	¥	0.49
Ki-67 + cytology	53	100	100	34	¥	0.47
CEA + cytology	71	42	83	26	1	0.7
CA19-9 + cytology	69	75	92	38	3	0.41
p53+Ki-67 + cytology	57	100	100	36	¥	0.43
p53+Ki-67 + CEA+cytology	80	42	85	33	1	0.49
p53+Ki-67 + CA19-9 + cytology	80	75	93	47	3	0.27
All 4 stains + cytology	86	42	86	42	1	0.34

CEA: carcinoembryonic antigen; IH: immunohistochemistry; NLR: negative likelihood ratio; NPV: negative predictive value; PLR: positive likelihood ratio; PPV: positive predictive value.