Osteoclastic and pleomorphic giant cell tumors of the pancreas: A review of clinical, endoscopic, and pathologic features

Figure 1 Osteoclastic giant cell tumor of pancreas. A: Endoscopic-ultrasound guided fine needle aspirate specimen of a pancreatic mass. The smear slide contains a loose admixture of osteoclastic-giant cells admixed with oval to polygonal mononuclear cells (a-arrow). The individual giant cells have multiple bland appearing nuclei. The pleomorphic mononuclear cells are usually more numerous than the giant cells (b-arrow). (Romanowsky stain); B: A tissue section from the pancreatectomy specimen. The neoplasm contains a scattering of osteoclastic multinucleated giant cells with bland nuclei (arrows). These giant cells lie in a background of atypical mononuclear cells with pleomorphic nuclei. (HE stain).