Prospective randomized study comparing Franseen 22-gauge vs standard 22-gauge needle for endoscopic ultrasound guided sampling of pancreatic solid lesions

Table 7 Randomized clinical trials comparing fine needle aspiration vs fine needle biopsy needles for endoscopic ultrasound-guided sampling of solid pancreatic tumors

Ref.	FNA (n)	FNB (n)	ROSE	Randomization	Technique of sampling	Sensitivity for malignancy (95%CI)-FNA	Sensitivity for malignancy (95%CI)-FNB	P value	Accuracy malignancy (95%CI)-FNA	Accuracy malignancy (95%CI)-FNB	P value
Bang et al[14]	22-gauge (28)	Reverse bevel (28)	Yes	Sequence of the needle	Capillarity and dry suction				100	83.3	0.26
Bang et al[15]	22-gauge (46)	Franseen 22-gauge (46)	Yes	Sequence of the needle					82.6	97.8	0.03
Noh et al[16]	22-gauge (30)	Reverse bevel 22-gauge (30)	Yes	Sequence of the needle	Dry suction				95	93.3	0.564
Vanbiervliet et al[17]	22-gauge (39)	Reverse bevel 22-gauge (41)	Yes	First needle FNA	Dry suction				92.5	90	0.68
Mavrogenis et al[18]	22-gauge (19)	Reverse bevel 25-gauge (19)	No	Sequence of the needle	Capillarity and dry suction	89.5 (66.82-98.39)	89.5 (66.82-98.39)		84.8 (67.3-94.2)	84.8 (67.3-94.2)
Kovacevic et al[19]	22-gauge (33)	22-gauge (31)	No	Sequence of the needle	Capillarity	65.5%	89.7%	> 0.5	69.7 (51.3-84.4)	90.3 (74.2-98%)
Our study	22-gauge (50)	Franseen 22-gauge (50)	No	Sequence of the needle	Capillarity and dry suction	0.83 (0.69-0.92)	0.91 (0.80-0.98)		0.84 (0.71-0.93)	0.92 (0.81-0.98)

CI: Confidence interval; FNA: Fine needle aspiration; FNB: Fine needle biopsy; ROSE: Rapid onsite evaluation.