Discordance between endoscopic and histopathologic assessment in ileal Crohn’s disease

Table 1 Histologic assessment of biopsies collected from patients with ileal Crohn’s disease with or without an endoscopically visible ulcer in the terminal ileum, n (%)/mean ± SD

Histology	Ulcer group			No ulcer controls
	Ulcer edge	7 mm from ulcer	14 mm from ulcer
Total sample
Ulcer subscore1	8 (33)	0	0	0
Active (neutrophilic) histologic inflammation2	16 (67)	7 (29)	4 (17)	3 (8)
Chronic (lymphoplasmacytic) histologic inflammation3	11 (46)	5 (21)	2 (8)	1 (3)
RHI
Total sample	11.1 ± 10.6	2.0 ± 2.9	1.5 ± 3.1	0.9 ± 1.7
Subset with active histologic inflammation2	16.6 ± 8.8	6.1 ± 1.2	7.5 ± 3.9	6 ± 0
GHAS
Total sample	6.5 ± 4.8	2.3 ± 3.2	1.9 ± 2.7	1.1 ± 1.9
Subset with active histologic inflammation2	8.8 ± 3.7	5.3 ± 2.8	6.3 ± 2.8	5.7 ± 1.2
PHRI
Total sample	1.9 ± 1.6	0.4 ± 0.7	0.4 ± 0.8	0.1 ± 0.5
Subset with active histologic inflammation2	2.9 ± 1.1	1.1 ± 0.9	1.8 ± 0.5	1.3 ± 1.2
Large (0.5-2 cm) or very large (> 2 cm) ulcers4
Ulcer subscore1	8 (42)	0	0
Active (neutrophilic) inflammation2	16 (84)	6 (32)	4 (21)
Chronic (lymphoplasmacytic) inflammation3	11 (58)	4 (21)	2 (11)
Aphthous ulcers (0.1-0.5 cm)5
Ulcer subscore1	0	0	0
Active (neutrophilic) inflammation2	0	1 (20)	0
Chronic (lymphoplasmacytic) inflammation3	0	1 (20)	0

¹Ulcer subscore (= 1 on Global Histology Activity Score and > 1 on Robarts Histopathology Index ulcer/erosion subscore).

²Active inflammation (Robarts Histopathology Index > 3).

³Chronic inflammation (Robarts Histopathology Index subscore of mononuclear cell infiltration > 1).

⁴Large or very large ulcers were those who had an ileal simple endoscopic score for Crohn’s disease > 3.

⁵Apthus ulcers were those who had an ileal simple endoscopic score for Crohn’s disease that was equal to 3.

GHAS: Global Histology Activity Score; RHI: Robarts Histopathology Index; PHRI: Picasso Histological Remission Index.