Leucine-rich alpha-2 glycoprotein as a superior biomarker to C-reactive protein for detecting small bowel lesions in Crohn’s disease

doi:10.4253/wjge.v17.i2.100793

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Feb 16, 2025 (publication date) through Feb 13, 2025

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Feb 16, 2025; 17(2): 100793
Published online Feb 16, 2025. doi: 10.4253/wjge.v17.i2.100793

Table 3 Area under curves, cut-off value, sensitivity, specificity, and accuracy of leucine-rich alpha-2 glycoprotein and C-reactive protein in predicting endoscopic healing in the ileum and colon

Ileum/colon	Variables	AUC (95%CI)	Cutoff value	Sensitivity (95%CI)	Specificity (95%CI)	Accuracy	P value (95%CI)
Ileum	LRG	0.809 (0.724-0.894)	12.4 μg/mL	0.767 (0.623-0.869)	0.787 (0.669-0.871)	0.779	0.024 (0.017-0.194)
Ileum	CRP	0.705 (0.602-0.808)	0.20 mg/dL	0.465 (0.325-0.611)	0.869 (0.762-0.932)	0.702	0.024 (0.017-0.194)
Colon	LRG	0.863 (0.747-0.978)	12.4 μg/mL	0.875 (0.640-0.978)	0.787 (0.669-0.871)	0.805	0.295 (-0.050 to 0.166)
Colon	CRP	0.805 (0.689-0.921)	0.13 mg/dL	0.750 (0.505-0.898)	0.738 (0.616-0.832)	0.740	0.295 (-0.050 to 0.166)

AUC: Area under the curve; CI: Confidence interval; LRG: Leucine-rich alpha-2 glycoprotein; CRP: C-reactive protein; EH: Endoscopic healing.

Citation: Ohno M, Nishida A, Otsuki A, Yokota Y, Imai T, Bamba S, Inatomi O. Leucine-rich alpha-2 glycoprotein as a superior biomarker to C-reactive protein for detecting small bowel lesions in Crohn’s disease. World J Gastrointest Endosc 2025; 17(2): 100793
URL: https://www.wjgnet.com/1948-5190/full/v17/i2/100793.htm
DOI: https://dx.doi.org/10.4253/wjge.v17.i2.100793