Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention

Table 1 Correlation coefficients between degree of histological atrophy and level of pepsinogen-1

Biopsy	Focus of a biopsy according to the Kimura-Takemoto classification	Spearman’s rank correlation coefficient
C2	Border of atrophy on the lesser curvature in the lower third of the gastric corpus	-0.03 (P > 0.05)
C3	Border of atrophy on the lesser curvature in the middle third of the gastric corpus	-0.13 (P > 0.05)
O1	Boundary between the lesser curvature and the anterior wall of the gastric corpus	-0.26 (P < 0.05)
O2	Border of atrophy within the anterior wall of the gastric corpus	-0.44 (P < 0.001)
O3	Boundary between the posterior wall of the gastric corpus and large curvature	-0.46 (P < 0.001)