Review
Copyright ©The Author(s) 2023.
World J Gastrointest Endosc. Mar 16, 2023; 15(3): 84-102
Published online Mar 16, 2023. doi: 10.4253/wjge.v15.i3.84
Table 1 Summary of the pathogenesis of gastroesophageal reflux disease
Main underlying mechanism
Associated conditions
Mechanism of GERD
Anatomical defectHiatus hernia, immature esophageal anti-relux barrier, e.g., infants, surgical pull up for esophageal atresiaIncreased risk of GER
Esophageal or gastric hypomotility/dysmotilityEsophageal disorders associated with dysmotility, e.g., esophageal atresia, achalasia, gastroparesis, cow’s milk protein allergy, sleeping, decreased saliva secretion, supine positionImpaired esophageal clearance of refluxate by peristalsis and/or production of neutralizing secretions
Esophageal mucosal defectEosinophilic esophagitis, esophageal infectionImpaired esophageal sensation
UES dysfunctionExtraesophageal or respiratory manifestationsAllows refluxate to access airways