Quality of bowel preparation in patients with inflammatory bowel disease undergoing colonoscopy: What factors to consider?

Table 1 Anterograde and retrograde bowel preparation regimens studied in patients with inflammatory bowel disease

Ref.	Year	Design	n	IBD	Bowel preparation	Split dosing considered	Low fiber diet considered	Main result (success), %	Post-colonoscopy IBD flare-up rate, % (days after colonoscopy)	Severe AEs
Gould et al[13]	1982	CT	23	UC: 23	Castor oil 30 mL	-	YES	82.6	26 (14-21 d)	NO
Gould et al[13]	1982	CT	23	UC: 23	Sennosides 75 mg	-	YES	86.9	48 (14-21 d)	NO
Lazzaroni et al[15]	1993	CT	48	UC: 26; CD: 23	4 L PEG-ELS plus placebo	YES	-	96	-	NO
Lazzaroni et al[15]	1993	CT	57	UC: 35; CD: 21	4 L PEG-ELS plus simethicone	YES	-	96	-	NO
Manes et al[53]	2015	CT	106	UC: 106	2 L PEG plus bisacodyl	YES	YES	83	-	NO
Manes et al[53]	2015	CT	105	UC: 105	4 L PEG-ELS	YES	YES	77.1	-	NO
Kim et al[22]	2017	CT	53	UC: 53	4 L PEG-ELS	YES	YES	96.2	5.7 (7 d); 1.9 (28 d)	NO
Kim et al[22]	2017	CT	56	UC: 56	2 L PEG plus ascorbate	YES	YES	92.9	3.6 (7 d); 1.8 (28 d)	NO
Briot et al[31]	2019	nCT Prospective		UC: 21; CD: 57; Unspecified IBD: 2	Picosulphate-based regimen	YES	YES	78.4	0	NO
Bezzio et al[39]	2020	nCTProspective	189	UC: 63; CD: 63	2 L PEG-ELS plus simethicone	YES	-	UC: 89.8; CD: 86.2	-	NO
Maida et al[25]	2021	nCT Retrospective	185	UC: 95; CD: 90	1 L PEG plus ascorbate solution	YES	YES	92.9	-	NO
Mohsen et al[30]	2021	CT	61	-	2 L Sodium; picosulphate, magnesium citrate PEG	YES	YES	89.5	-	NO
Mohsen et al[30]	2021	CT	64	-	2 L PEG plus ascorbate solution	YES	YES		-	NO
Neri et al[29]	2021	nCT Prospective	103	UC: 47; CD: 56	1 L PEG-ELS	YES	YES	85.4	-	NO
Kim et al[32]	2022	nCT Prospective	52	UC: 35; CD: 17	2 L PEG plus ascorbate	YES	YES	98.1	0 (7 and 28 d)	NO
Kim et al[32]	2022	nCT Prospective	55	UC: 37; CD: 18	Novel oral sulphate tablets	YES	YES	98.1	3,63 (7 and 28 d)	NO
Gajera et al[51]	2022	nCT Retrospective	318	UC: 182; CD: 104; Unspecified IBD: 28	Colonic lavage	Not applicable	YES	97	-	NO

IBD: Inflammatory bowel disease; PEG: Polyethylene glycol; ELS: Electrolyte lavage solution; UC: Ulcerative colitis; CD: Crohn’s disease; CT: Clinical trial; nCT: Non-clinical trial.