Stenting as a bridge to surgery in obstructing colon cancer: Long-term recurrence pattern and competing risk of mortality

Table 3 Fine-Gray regression analysis for colorectal cancer-specific death under the competing risk of other cause-specific death

Variable	CRC-specific death
	Univariate		Multivariate
	SHR (95%CI)	P value	SHR (95%CI)	P value
Age ≥ 70 yr	0.84 (0.33, 2.15)	0.710
Sex (Male)	0.49 (0.19, 1.28)	0.150
Laparoscopic surgery	1.28 (0.49, 3.33)	0.610
Stent failure	0.58 (0.06, 5.51)	0.630
T4 staging	1.23 (0.97, 1.57)	0.088
N2	2.44 (0.88, 6.75)	0.086
Tumour deposit(s)	2.02 (0.74, 5.56)	0.170
Microscopic margin involvement (R1 resection)	1.68 (0.58, 4.84)	0.340
Mucinous components	3.35 (0.72, 15.5)	0.120
Poorly differentiated	2.67 (1.50, 4.76)	< 0.001	1.11 (0.32, 3.83)	0.870
Perineural infiltration	2.34 (0.89, 6.17)	0.086
Lymphovascular invasion	3.99 (1.55, 10.3)	0.004	1.98 (0.61, 6.49)	0.260
Pericolic microabscess	1.12 (0.25, 5.04)	0.880
Albumin < 3.0 g/dL	1.36 (0.38, 4.90)	0.640
CEA ≥ 5.3 µg/L	2.45 (0.80, 7.53)	0.120
ASA classification III	1.10 (0.68, 1.80)	0.700
Diabetes mellitus	2.02 (0.75, 5.49)	0.170
Perioperative major complication(s)	1.26 (0.16, 9.78)	0.820
Adjuvant chemotherapy	1.37 (0.54, 3.46)	0.500
Lung-only recurrence	0.69 (0.19, 2.51)	0.570
Liver-only recurrence	4.25 (0.98, 18.4)	0.049	41.0 (5.01, 336)	< 0.001
Peritoneum-only recurrence	4.53 (1.79, 11.5)	0.001	23.2 (2.92, 185)	0.003
≥ 2 sites of recurrences	1.96 (1.19, 3.23)	0.008	5.28 (1.80, 15.4)	0.002

CRC: Colorectal cancer; SHR: Subdistribution hazard ratio; CI: Confidence interval; ASA: American Society of Anaesthesiologists; CEA: Carcinoembryonic antigen.