The role of computed tomography for the prediction of esophageal variceal bleeding: Current status and future perspectives

Table 2 Demographics and clinicopathological features of the included studies

Ref.	Patients, n	Mean age (range), years	Sex male, %	Cirrhosis etiology, %	Child-Pugh class, %	MELD score
Somsouk et al[28], 2014	80 (cases: 27; controls: 53)	Cases: 58 (-); Controls: 55 (-)	Cases: 96; Controls: 96	HCV: 71 (cases); 77 (controls); HBV: 0 (cases); 9 (controls); Alcoholic: 83 (cases); 64 (controls)	-	-1
Ge et al[29], 2015	98 (cases: 57; controls: 41)	Cases: 49.9 (-); Controls: 53.9 (-)	56	HBV: 100	A: 15 (cases); 28 (controls); B: 21 (cases); 12 (controls); C: 5 (cases); 4 (controls)	-
Calame et al[30], 2017	172 (cases: 43; controls: 129)	Cases: 59.6 (12-85); Controls: 60.2 (33-86)	Cases: 77; Controls: 62	Alcoholic: 77 (cases); 70 (controls); NASH: 9 (cases); 13(controls) HCV: 9 (cases); 9 (controls); HBV: 7 (cases); 4 (controls); Other: 5 (cases); 13 (controls)	A: 16 (cases); 43 (controls); B: 46 (cases); 27 (controls); C: 37 (cases); 29 (controls)	-
Kim et al[31], 2019	309 (cases: 37; controls: 272)	Cases: 58 (-); Controls: 58 (-)	Cases: 81; Controls: 72	HBV: 46 (cases); 61 (controls); HCV: 16 (cases); 7 (controls); Non-B/C: 38 (cases); 32 (controls)	A: 57 (cases); 48 (controls); B: 40 (cases); 44 (controls); C: 3 (cases); 8 (controls)	-
Salahshour et al[32], 2020	124 (cases: 50; controls: 74)	Cases: 49.2 (-); Controls: 52.14 (-)	Cases: 46; Controls: 54	HBV: 24.2; HCV: 5.6; BCS: 8.1; Alcoholic: 9.7; NASH: 14.5; ASH: 4.0; PSC: 9.7; Wilson disease: 2.4; PBC: 1.6; Cryptogenic: 10.5; Other: 9.7	-2	-2
Xie et al[33], 2020	264 (cases: 132; controls: 132)	Cases: 54 (30-76); Controls: 54 (25-79)	Cases: 85%; Controls: 88%	HBV: 87 (cases); 95 (controls); Alcoholic: 11 (cases); 1 (controls); HCV: 2 (cases); 4 (controls)	-	-
Peisen et al[34], 2021	66 (cases: 8; controls: 58)	68	89	HCV: 32; Alcoholic: 48; Cryptogenic: 14; HBV: 6	A: 53%; B: 38%; C: 9%	-
Wan et al[35], 2021	217 (cases: 17; controls: 27)	Cases: 52.8; Controls: 52.4	Cases: 53; Controls: 56	Post-hepatic: 53 (cases); 41 (controls); Alcoholic: 18 (cases); 15 (controls); PBC: 29 (cases); 19 (controls); Mixed: 0 (cases); 7 (controls) Other: 0 (cases); 19 (controls)	A: 47 (cases); 33 (controls); B: 35 (cases); 33 (controls); C: 18 (cases); 33 (controls)	-
Wan et al[36], 2022	136 (cases: 89; controls: 47)	-	63	Post-hepatic: 60; Alcoholic: 25; PBC: 9; Mixed: 4; AIH: 1	A: 28; B: 46; C: 26	-

¹No significant difference between case and control groups.

²Significant difference between case and control groups.

MELD: Model for end-stage liver disease; HCV: Hepatitis C virus; HBV: Hepatitis B virus; NASH: Nonalcoholic steatohepatitis; BCS: Budd-Chiari syndrome; AIH: Autoimmune hepatitis; PSC: Primary sclerosing cholangitis; PBC: Primary biliary cirrhosis.