Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions

Table 8 Value of different variables in predicting malignancy

Variable	Criterion	Specificity	Sensitivity	PPV	NPV	P value	AUC
Age	> 35	0.244	1	0.4745	1	0.605	0.534
Mucin stain		0.9556	0.871	0.931	0.9149	< 0.001	0.913
Glucose (mg/dL)	≤ 42	0.7353	0.8478				0.76
IL1b (pg/mL)	< 1.13	0.209	0.9	0.4363	0.7464	0.761	0.521
CA 72-4 (U/mL)	> 4.3138	0.467	0.677	0.4657	0.678	0.32	0.567
VEGF-A (pg/mL)	> 1221.7	0.844	0.29	0.561	0.634	0.87	0.511
VEGFR2 (pg/ml)	> 6.601	0.933	0.29	0.7482	0.657	0.301	0.573
SPINK1 (μg/L)	≥ 0.58	0.6533	0.7059	0.708	0.623		0.72
PGE2 (pg/ml)	> 311.77	0.556	0.8	0.5529	0.802	0.102	0.683
CF amylase (U/L)	> 270	0.71	0.711	0.629	0.781	0.028	0.644
CF CEA (ng/ml)	> 8	0.742	0.689	0.622	0.795	< 0.001	0.761

CA: Cancer antigen; CF: Cyst fluid; VEGFR2: Vascular endothelial growth factor receptor 2; PPV: Positive predictive value; NPV: Negative predictive value.