Meta-Analysis
Copyright ©The Author(s) 2022.
World J Gastrointest Endosc. Nov 16, 2022; 14(11): 718-730
Published online Nov 16, 2022. doi: 10.4253/wjge.v14.i11.718
Table 1 Characteristics of included studies
Ref.
Year
Type of study
Intervention
Participants
Bacteremia
Cholangitis
Pancreatitis
Septicemia
Mortality
Brandes et al[23]1981RCTMinocycline 300 mg orallyTotal: 118N/AIntervention: 0/39Intervention: 1/39N/AN/A
Antibiotics: 39Control: 1/79Control: 2/79
Control: 79
Sauter et al[22]1990RCTCefotaxime 2 g IV, 15 min before ERCPTotal: 100Intervention: 1/50Intervention: 1/50Intervention: 0/50Intervention: 0/50Intervention: 0/50
Antibiotics: 50Control: 8/50Control: 2/50Control: 0/50Control: 0/50Control: 0/50
Control: 50
Niederau et al[21]1994RCTCefotaxime 2 g IV. 15 min before ERCPTotal: 100Intervention: 0/50Intervention: 0/50Intervention: 2/50Intervention: 0/50Intervention: 0/50
Antibiotics: 50Control: 4/50Control: 4/50Control: 3/50Control: 8/50Control: 0/50
Control: 50
Byl et al[20]1995RCTPiperacillin, 4 g IV, 3/dTotal: 68Intervention: 0/30Intervention: 2/34N/AIntervention: 0/30Intervention: 0/34
Antibiotics: 34Control: 7/32Control: 10/34Control: 5/32Control: 5/34
Control: 34
Finkelstein et al[27]1996RCTCefonicid 1 g IV, 1 h before ERCPTotal: 179Intervention: 3/88Intervention: 7/88N/AIntervention: 0/88Intervention: 0/88
Antibiotics: 88Control: 2/91Control: 2/91Control: 0/91Control: 0/91
Control: 91
Lorenz et al[24]1996RCTCefuroxime 1.5 g IV, 30 min before ERCPTotal: 99Intervention: 3/49N/AN/AIntervention: 3/49Intervention: 0/49
Antibiotics: 49Control: 8/50Control: 5/50Control: 0/50
Control: 50
van den Hazel et al[19]1996RCTPiperacillin 4 g IV, 30 min before ERCPTotal: 551N/AIntervention: 12/170N/AIntervention: 2/170Intervention: 3/170
Antibiotics: 270Control: 17/281Control: 3/281Control: 2/281
Control: 281
Räty et al[18]2001RCT2g of ceftazidime IV, 30 min before ERCPTotal: 315N/AIntervention: 0/155Intervention: 4/155N/AIntervention: 1/155
Antibiotics: 155Control: 7/160Control: 15/160Control: 0/160
Control: 160
Spicak et al[26]2002RCTAmoxicillin – clavulanic acid 2.4 g IVTotal 165Intervention: 18/73Intervention: 4/77Intervention: 6/77N/AIntervention: 2/77
Antibiotics: 77Control: 24/84Control: 3/88Control: 10/88Control: 2/88
Control: 88
Llach et al[25]2006RCTClindamycin 600 mg and gentamicin 80 mg IM, 1 h before ERCPTotal: 62Intervention: 2/31Intervention: 1/31N/AIntervention: 0/31Intervention: 0/31
Antibiotics: 31Control: 2/30Control: 1/31Control: 0/30Control: 0/30
Control: 31

  • Citation: Merchan MFS, de Moura DTH, de Oliveira GHP, Proença IM, do Monte Junior ES, Ide E, Moll C, Sánchez-Luna SA, Bernardo WM, de Moura EGH. Antibiotic prophylaxis to prevent complications in endoscopic retrograde cholangiopancreatography: A systematic review and meta-analysis of randomized controlled trials. World J Gastrointest Endosc 2022; 14(11): 718-730
  • URL: https://www.wjgnet.com/1948-5190/full/v14/i11/718.htm
  • DOI: https://dx.doi.org/10.4253/wjge.v14.i11.718