Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases

Table 5 Logistic regression analyses to assess the association of decompression method (predictor) with severe venous invasion (outcome)

Model for severe venous invasion (n = 102, as a binary outcome variable)	Univariable		Multivariable1		Multivariable2
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Decompression methods
Transanal tube	1 (reference)	< 0.0001	1 (reference)	< 0.0001	1 (reference)	< 0.0001
SEMS	20.9 (5.78-101)		19.4 (5.24-96.2)		36.7 (7.89-259)
Age (for 10-yr increment)	1.29 (0.82-2.20)	0.28
Sex
Female	1 (reference)	0.60
Male	1.34 (0.44-4.14)
Tumor location
Cecum to transverse colon	1 (reference)	0.27			1 (reference)	0.27
Descending to sigmoid colon	0.88 (0.23-4.31)				0.38 (0.05-2.60)
Rectum	0.22 (0.01-1.90)				0.11 (0.003-1.58)
Waiting period (for 1-wk increment)	0.91 (0.47-1.22)	0.64
Tumor size (for 10-mm increment)	1.10 (0.78-1.49)	0.55
Histological type
Well	1 (reference)	0.21			1 (reference)	0.065
Moderate	2.65 (0.65-17.9)				7.27 (1.27-64.5)
Mucinous, poor, or signet-ring cell	6.75 (0.66-72.0)				10.7 (0.48-342)
AJCC-pT
T2/T3	1 (reference)	0.021	1 (reference)	0.084	1 (reference)	0.082
T4	3.72 (1.22-12.2)		3.17 (0.86-12.6)		3.76 (0.85-19.4)
Mutation
Absent	1 (reference)	0.81
Present (KRAS, NRAS)	1.16 (0.33-4.07)

¹The multivariable logistic regression model included the decompression method (transanal tube vs SEMS), and AJCC-pT (T2/T3 vs T4).

²The multivariable logistic regression model included the decompression method (transanal tube vs SEMS), tumor location (cecum to transverse colon vs descending to sigmoid colon vs rectum), histological type (well-differentiated vs. moderately differentiated vs others), and AJCC-pT (T2/T3 vs T4).

AJCC: American Joint Committee on Cancer; CI: Confidence interval; OR: Odds ratio; SEMS: Self-expanding metal stent.