Effect of pancreatic endotherapy on quality of life in chronic pancreatitis patients: A systematic review

Table 1 Key characteristics of included articles

Ref.	Study design	Endoscopic modality	n	Quality of life measurement	Quality of life findings
Cahen et al[18,19]	Randomized clinical trial	ERCP ± ESWL	19	SF-36	Physical health: 31 ± 8 to 38 ± 9 (2 yr) and 43 ± 11 (7 yr); Mental health: 33 ± 8 to 40 ± 9 (2 yr) and 46 ± 9 (7 yr)
Issa et al[20]	Randomized clinical trial	ERCP ± ESWL	44	SF-36	Physical health: 31 ± 8 to 36 ± 9; Mental health: 36 ± 11 to 41 ± 11
Stevens et al[31]	Randomized study	Celiac plexus block	40	SF-12	Change in physical score: -0.2 ± 7.5 (triamcinolone + bupivacaine), 1.7 ± 8.8 (bupivacaine); Change in mental score: 1.3 ± 10.0 (triamcinolone + bupivacaine), -2.1 ± 12.9 (bupivacaine)
Brand et al[22]	Prospective study	ERCP + ESWL	48	EORTC	Pain: 37.8 (range 0-81.5) to 18.8 (range 0-83.3); Weight loss: 66.7 (range 0-100) to 0 (range 0-100); Global quality of life: 41.7 (range 16.7-100) to 58.3 (range 8.3-100)
Hu et al[24]	Prospective study	ERCP + ESWL	214	SF-36	Physical health: 56.9 ± 18.7 to 59.2 ± 14.8 (no significant difference); Patients with pseudocysts: 95 (range 35-100) to 100 (range 75-100); Mental health: 52.2 ± 21.5 to 58.5 ± 16.4; Patients with pseudocysts: 68 (range 36-100) to 76 (range 28-100)
Milovic et al[27]	Prospective study	ERCP + ESWL	32	1-5 scale	4 (range 2-5) to 2.5 (range 1-4)
Basiński et al[32]	Prospective study	Celiac plexus block	92	EORTC	Quality of life significantly improved with greatest improvement seen in those with high religiosity
Rutter et al[21]	Retrospective study	ERCP	150	EORTC	Patients treated with surgery had less nausea/vomiting compared to those treated with endoscopy
Tandan et al[23]	Retrospective study	ERCP + ESWL	636	1-10 scale	252 (92.6%) patients had improved quality of life
Seven et al[26]	Retrospective study	ERCP + ESWL	120	1-10 scale	3.7 ± 2.4 to 7.3 ± 2.7
Gerges et al[28]	Retrospective study	Pancreatoscopy-guided lithotripsy	20	Generic quality of life instrument	89% had no or only mild disability in daily activities, 47% had “excellent” or “very good” general health
Vitale et al[29]	Retrospective study	Minor papilla stenting	32	Generic quality of life survey	100% stated improved quality of life, 100% stated satisfaction with treatment

ERCP: Endoscopic retrograde cholangiopancreatography; ESWL: Extracorporeal shock-wave lithotripsy; SF: Short Form Health Survey; EORTC: European Organisation for Research and Treatment of Cancer.