Crohn’s strictures open with anti-mycobacterial antibiotic therapy: A retrospective review

Table 2 Comparison of stricture outcomes in the thirty patients that returned for follow-up

	CR (n = 20)	PR + NR (n = 10)	P value
Demographics
Age at AMAT [yr (IQR)]	28 (24-32)	26 (25-47)	0.66
Sex (M)	11	4	0.70
Duration of disease [yr (IQR)]	4 (1-8)	2 (1-4)	0.45
Time between diagnosis and stricture [yr (IQR)]	3 (0-6)	1.5 (0-3)	0.54
Stricture outcome
Single stricture, n (%)	19 (95)	7 (70)	0.10
Multiple strictures, n (%)	1 (5)	3 (30)
Clinical outcome
Clinical response, n (%)	16 (80)	5 (50)	0.12
No clinical response, n (%)	4 (20)	5 (50)
Pathology
CRP [mg/L (IQR)]	4 (3-10)	6 (4-8)	0.71
ESR [mm/h (IQR)]	5 (2-9)	6 (4-11)	0.86
Area of involvement
ICV, n (%)	8 (40)	4 (40)
TI, n (%)	12 (60)	5 (50)
ICV + TI, n (%)	0 (0)	1 (10)
Duration of AMAT for stricture outcome
≤ 12 mo, n (%)	10 (50)	3 (30)	0.44
> 12 mo, n (%)	10 (50)	7 (70)

Clinical outcomes: (1) Clinical response with complete resolution (CR): n = 16 (7, asymptomatic; 9, improved); (2) clinical response with partial resolution (PR) + no resolution (NR): n = 5 (1, asymptomatic; 4, improved); (3) no clinical response with CR: n = 4 (4, no change); and (4) no clinical response with PR + NR: n = 5 (4, no change; 1, worsened). CR: Complete resolution; PR: Partial resolution; NR: No resolution; AMAT: Anti-mycobacterial antibiotic therapy; IQR: Interquartile range; M: Male; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; ICV: Ileocecal valve; TI: Terminal ileum.