Assessing the yield and safety of endoscopy in acute graft-vs-host disease after hematopoietic stem cell transplant

Table 3 Gross endoscopic findings and concurrent presence of mild, moderate, and severe graft-vs-host disease

Endoscopic finding	Patients with GVHD, % (n)	Sensitivity (%)	Specificity (%)	Patients with mild GVHD, % (n)	Patients with moderate GVHD, % (n)	Patients with severe GVHD, % (n)
Normal1	84.0 (21/25)	14.1	91.3	100.0 (21/21)	4.8 (1/21)	0 (0/21)
General findings1
Edema/erythema	82.4 (89/108)	59.7	58.7	88.8 (79/89)	30.3 (27/89)	12.4 (11/89)
Ulceration/erosion	80.4 (45/56)	30.2	76.1	77.8 (35/45)	40.0 (18/45)	26.7 (12/45)
Friability	90.9 (10/11)	6.7	97.8	80.0 (8/10)	30.0 (3/10)	20.0 (2/10)
Nodule	80.0 (4/5)	2.7	97.8	100.0 (4/4)	50.0 (2/4)	25.0 (1/4)
Specific findings2
Gastritis	84.5 (60/71)	72.3	78.6	95.0 (57/60)	16.7 (10/60)	1.7 (1/60)
Duodenitis	66.7 (14/21)	16.1	88.9	78.6 (11/14)	21.4 (3/14)	21.4 (3/14)
Colitis	97.1 (33/34)	30.3	93.0	57.6 (19/33)	42.4 (14/33)	24.2 (8/33)
Esophagitis	66.7 (14/21)	70.0	94.3	100.0 (14/14)	0 (0/14)	0 (0/14)

¹We did not localize these endoscopic findings to a particular segment of the gastrointestinal (GI) tract. Diagnostic yield, sensitivity, and specificity calculated were for finding graft-vs-host disease (GVHD) anywhere in the GI tract.

²Patients in the “Specific Findings” category had endoscopic evidence of inflamed mucosa in a specific segment of the GI tract along with biopsy taken from this segment. Diagnostic yields, sensitivities, and specificities calculated were for finding histopathological evidence of GVHD in this specific segment of the GI tract. GVHD: Graft-vs-host disease.