Assessing the yield and safety of endoscopy in acute graft-vs-host disease after hematopoietic stem cell transplant

Table 2 Yield of performing different endoscopic modalities in detecting graft-vs-host disease in patients with different presenting symptoms

Endoscopic procedure	Confirmed GVHD in patients with any symptom, % (n)	Confirmed GVHD in patients presenting with diarrhea, % (n)	Confirmed GVHD in patients presenting with nausea/vomiting, % (n)	Confirmed GVHD in patients presenting with abdominal pain, % (n)
EGD (n = 45)	66.7 (30/45)	85.7 (6/7)1	70.6 (24/34)	57.1 (8/14)
FS (n = 57)	77.2 (44/57)	76.8 (43/56)	87.5 (7/8)2	76.9 (10/13)
Colonoscopy (n = 4)	75.0 (3/4)	75.0 (3/4)	-	100.0 (1/1)
EGD + FS (n = 83)	83.1 (69/83)	84.9 (62/73)	85.9 (55/64)	90.5 (19/21)
EGD + colonoscopy (n = 6)	50.0 (3/6)	50.0 (2/4)	0 (0/1)	100.0 (1/1)

¹Three of six patients who presented with diarrhea and underwent esophagogastroduodenoscopy with confirmed graft-vs-host disease (GVHD) also had nausea/vomiting at time of presentation.

²Seven of seven patients who presented with nausea/vomiting and underwent FS with confirmed GVHD also had diarrhea at time of presentation. EGD: Esophagogastroduodenoscopy; FS: Flexible sigmoidoscopy; GVHD: Graft-vs-host disease.