Endoscopic retrograde cholangiopancreatography guided interventions in the management of pancreatic cancer

Table 2 Prospective/retrospective studies on the diagnostic yield of endoscopic retrograde cholangiopancreatography guided brush cytology for malignant biliary stricture

Ref.	Year	No. of patients	No of patients with malignant strictures	TP on brush cytology	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Moura et al[10]	2018	50	48	40	40	100	100	7
Agarwal et al[21]	2018	40	40	27	68	NA	NA	NA
Sethi et al[33]	2016	162	106	58	55	100	100	54
Shieh et al[22]	2014	32	32	25	78	NA	NA	NA
Weber et al[36]	2008	58	58	24	41	NA	NA	NA
Kitajima et al[37]	2007	60	NA	NA	72	100	NA	NA
Fogel et al[23]	2006	102	94	28	30	NA	NA	NA
Rösch et al[15]	2004	50	28	28	46	100	NA	NA
Stewart et al[24]	2001	406	246	147	60	98	98	61
Macken et al[25]	2000	106	62	35	57	100	100	62
Jailwala et al[26]	2000	133	104	31	30	100	100	28
Glasbrenner et al[27]	1999	78	57	32	56	91	94	43
Mansfield et al[28]	1997	54	52	17	54	100	100	8
Sugiyama et al[35]	1996	43	31	25	48	100	NA	NA
Pugliese et al[29]	1995	94	64	35	54	100	100	50
Ponchon et al[30]	1995	210	128	45	35	97	96	44
Lee et al[31]	1995	149	106	40	37	100	100	39
Foutch et al[32]	1991	30	17	06	33	100	100	58
Pugliese et al[34]	1987	22	12	08	66	88	NA	NA
Total	-	1879	1285	651	541	1001	-	-

¹Median value of available data. TP: True positive; PPV: Positive predictive value; NPV: Negative predictive value; NA: Data not available. Decimal numbers are rounded off.