Randomized, double-blinded, placebo-controlled trial evaluating simethicone pretreatment with bowel preparation during colonoscopy

Table 5 Preparation efficacy end points, n (%)

	Simethicone, n = 84	Placebo, n = 84	P-value
Intraluminal Bubbles Scale
mean (± SD)	1.20 ± 0.60	1.77 ± 1.00	< 0.001
Low grade (I+II)	80 (55.6)	64 (44.4)	0.184
High grade (III + IV)	4 (16.7)	20 (83.3)	0.007
Boston Bowel Preparation Score (BBPS)
mean (± SD)	7.42 ± 1.51	7.28 ± 1.44	0.542
Mean cecal insertion time (± SD)	6.06 ± 3.55	5.48 ± 2.82	0.252
Mean withdrawal time (± SD)	11.73 ± 5.52	11.23 ± 3.99	0.500
No polyps	37 (49.3)	38 (50.7)	0.907
Total polyps	127 (56.7)	97 (43.3)	0.047
Adenomas	86 (65.6)	45 (34.4)	0.001
Sessile serrated polyps	4 (3.2)	7 (7.2)	0.163
Large polyps (> 5 mm), (mean ± SD)	1.13 ± 1.71	1.16 ± 1.27	0.937
Small polyps (1 mm - 4 mm), (mean ± SD)	1.56 ± 1.92	1.00 ± 1.14	0.093
Right sided polyps (mean ± SD)	1.23 ± 1.95	0.98 ± 0.96	0.429
Left sided polyps	1.53 ± 1.56	1.18 ± 1.19	0.228

BBPS was calculated out of total of 9. Intraluminal Bubbles Scale was calculated out of total of 4. Grade 1 was equivocal to > 90% mucosa clear of bubbles with no necessity of irrigation; Grade 2 was 75%-89% mucosa clear of bubbles with no necessity of irrigation; Grade 3 was 50%-74% mucosa clear of bubbles and required irrigation; Grade 4 was < 50% mucosa clear of bubbles and required irrigation. Total Polyps include hyperplastic polyps, benign polypoid mucosa, hyperplastic polyps, tubular adenomas, tubulovillous adenomas, and sessile serrated polyps. SD: Standard deviation. Mean cecal insertion time and mean withdrawal time values are denoted in minutes.