Spectrum of gastrointestinal involvement in Stevens - Johnson syndrome

Table 2 Spectrum of gastrointestinal involvement in Stevens - Johnson syndrome or total parenteral nutrition

Total reported cases	25
Age (range)	8-81 yr
M:F (ratio)	7:18
TBSA (%)	0%-95% (all patients except one had > 30% of skin involvement)
Time of appearance of GI symptoms	0 wk-7 wk (usually within two weeks) after appearance of rash/mucosal lesions
Chief symptoms	GI bleeding-17 (68%) Diarrhoea-13 (52%) Abdominal pain-10 (40%) Abdominal distension-3 (12%) Vomiting-2 (8%)
Complications/ Extent of GI involvement	Luminal erosions/inflammation-15 (60%) Ulcer (Single or multiple)-9 (36%) [Large bowel (6). Small bowel (3), Esophageal (3), Gastric (2)] Perforation-3 (12%) (small bowel/colon) Strictures-2 (8%) (ileal/ileo-colonic) Mesentric ischaemia/ Intestinal infarction/ Ileoileal intussusceptions,/ Pseudodiverticular sacs/ Intraabdominal abscess,/ Pseudomembranes formation/ Subacute intestinal obstruction-One each Malabsorption/ Hypoalbumenia/ Protein-losing enteropathy- One each
Treatment	Medical [Steroids (14), IVig (4), TPN (4), Probiotics (2), PP (1), PE (1), EN (1)] Surgery-8 (32%)
Outcome	Survived- 14 (56%) [LOS (range)- 10 d -9 mo, DOI (range)-1-6 mo] Expired-11 (44%)

TBSA: Total body surface area; GI: Gastrointestinal; M: Male; F: Female; TPN: Total parenteral nutrition; LOS: Length of stay; IVIg: Intravenous immunoglobulin; PE: Plasma exchange; EN: Enteral nutrition; DOI: Duration of illness.