White light endoscopy, narrow band imaging and chromoendoscopy with magnification in diagnosing colorectal neoplasia

Table 2 The Sn, Sp, PPV and NPV looking individually at the performances of each modality compared to the final histopathological diagnosis (95% CI)

	Sn	Sp	PPV	NPV
WLE
HP	14.3 (2.6, 51.3)	97.7 (87.9, 99.6)	50 (9.5, 90.5)	87.5 (75.3, 94.1)
A	73.7 (58.0, 85.0)	91.7 (64.6, 98.5)	96.6 (82.8, 99.4)	52.4 (32.4, 71.7)
C	80.0 (37.6, 96.4)	97.8 (88.4, 99.6)	80 (37.6, 96.4)	97.8 (88.4, 99.6)
Overall	94.1 (80.9, 98.4)	6.3 (1.1, 28.3)	68.1 (53.8, 79.6)	33.3 (6.1, 79.2)
NBI (KPP)
HP	28.6 (8.2, 64.1)	100 (91.8, 100)	100 (34.2, 100)	89.6 (77.8, 95.5)
A	94.7 (82.7, 98.6)	100 (75.8, 100)	100 (90.4, 100)	85.7 (60.1, 96.0)
C	100 (56.6, 100)	97.8 (88.4, 99.6)	83.3 (43.6, 97.0)	100 (92.0, 100)
Overall	100 (91.4, 100)	22.2 (6.3, 54.7)	85.4 (72.8, 92.8)	100 (34.2, 100)
NBI (MCBN)
HP	100 (64.6, 100)	97.7 (87.9, 99.6)	87.5 (52.9, 97.8)	100 (91.6, 100)
A	94.7 (82.7, 98.6)	91.7 (64.6, 98.5)	97.3 (86.2, 99.5)	84.6 (57.8, 95.7)
C	80.0 (37.6, 96.4)	97.8 (88.4, 99.6)	80.0 (37.6, 96.4)	97.8 (88.4, 99.6)
Overall	95.2 (84.2, 98.7)	87.5 (52.9, 97.8)	97.6 (87.4, 99.6)	77.8 (45.3, 93.7)
NBI (COMBINED)
HP	100 (64.6, 100)	97.7 (87.9, 99.6)	87.5 (52.9, 97.8)	100 (91.6, 100)
A	94.7 (82.7, 98.6)	100 (75.8, 100)	100 (90.4, 100)	85.7 (60.1, 96.0)
C	100 (56.6, 100)	97.8 (88.4, 99.6)	83.3 (43.6, 97.0)	100 (92, 100)
Overall	97.6 (87.7, 99.6)	87.5 (52.9, 97.8)	97.6 (87.7, 99.6)	87.5 (52.9, 97.8)
CHR
HP	71.4 (35.9, 91.8)	97.7 (87.9, 99.6)	83.3 (43.6, 97.0)	95.5 (84.9, 98.7)
A	92.1 (79.2, 97.3)	100 (75.8, 100)	100 (90.1, 100)	80.0 (54.8, 93.0)
C	100 (56.6, 100)	97.8 (88.4, 99.6)	83.3 (43.6, 97.0)	100 (92.0, 100)
Overall	97.6 (87.4, 99.6)	55.6 (26.7, 81.1)	90.9 (78.8, 96.4)	83.3 (43.6, 97.0)

Sn: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; HP: Hyperplastic polyp; A: Adenomatous polyp; C: Carcinoma.