Ohio solid organ transplantation consortium criteria for liver transplantation in patients with alcoholic liver disease

Table 1 Ohio Solid Organ Transplantation Consortium medically urgent except criteria

	Ohio Solid Organ Transplantation Consortium Criteria
Low-risk	1 mo confirmed abstinence, a signed contract and commitment to begin a rehabilitation program and finish it either before or after transplant
	No previous failure with substance rehabilitation; never been told that substance was affecting health; and good social support
Medium-risk	Three month confirmed abstinence, a signed contract and commitment to begin a rehabilitation program and/or finish it either before or after transplant
	One or more failures with rehabilitation; and minimal support system
High-risk	Two or more failures to remain abstinent despite medical complication
	Refusal to sign contract
	Minimal to poor social support
	Must complete standard criteria treatment plan, not eligible for an exception
Other barriers	No insight into their alcohol use consequences
	No recognition that alcohol caused their liver failure
	Refusal to start treatment
	No sober support network

Table 2 Characteristics of study patients and controls

	Patients	Controls
At listing
n	36	72
Age, median (IQR)	58 (14)	60 (11)
Male, n (%)	23 (64)	46 (64)
INR, median (IQR)	1.8 (0.6)	1.9 (0.7)
Total Bilirubin, median (IQR)	8.9 (19.3)	5 (7.7)
Creatinine, median (IQR)	2.1 (2.4)	1.5 (2)
Albumin, median (IQR)	3.2 (0.9)	2.9 (1)
MELD, median (IQR)	27 (11)	24 (11)
At transplant
n	19	38
Age, median (IQR)	56 (17)	55 (13)
Male, n (%)	13 (68)	26 (68)
INR, median (IQR)	1.6 (0.5)	1.9 (0.8)
Total Bilirubin, median (IQR)	8.3 (12.1)	6 (5.7)
Creatinine, median (IQR)	2.6 (2.9)	1.3 (1.3)
Albumin, median (IQR)	2.9 (0.8)	2.8 (1)
MELD, median (IQR)	24 (13)	25 (9)

IQR: Inter-quartile range; INR: International normalized ratio; MELD: Model for end stage liver disease.

Table 3 Follow-up details of listed and transplanted patients and controls

	Patients	Controls	P-value
After listing
No. listed	36	72
No. transplanted (%)	19 (53)	41 (57)	0.6871
Waiting time for transplant, d, median (IQR)	19 (7-65)	21 (5-54)	0.6482
After transplant
No. transplanted	19	38
Follow-up after transplant, months, median (IQR)	41 (29-58)	37 (14-61)
1-yr survival, % ± SE	90 ± 7	92 ± 5	0.8373
5-yr survival, % ± SE	73 ± 12	77 ± 8

¹χ² test;

²P-value for patient vs control time to transplant Cox proportional hazards model;

³Log-Rank test. IQR: Inter-quartile range; SE: Standard error.