Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease

Figure 4 More genes are concordantly than oppositely regulated in alcoholic liver disease and non-alcoholic fatty liver disease. The chart shows the abundance of concordantly and oppositely regulated genes in KEGG pathways (for abundances > 3). The most abundant MAP2K1 (MEK1) refers to the MAPK/RAS-signalling module acting in many KEGG-pathways. JUN which is appearing in 17 KEGG pathways and is down-regulated in ALD and up-regulated in NAFLD shows that there are mechanistic differences in disease pathologies. ALD: Alcoholic liver disease; NAFLD: Non-alcoholic fatty liver disease.