Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C

Table 2 Summary of cut-off values, area under de curve, sensitivity, specificity, positive predictive value, negative predictive value and accuracy

Method	AUC	AUC CI (95%)	Se	Sp	PPV	NPV	Accuracy
TE (kPa)
> F2 (6.6)	0.8716	0.7953-0.948	82.90%	77.50%	89.30%	66.70%	80.20%
> F3 (8.9)	0.9187	0.8319-1.000	87%	86.20%	87.30%	85.90%	86.40%
= F4 (12.2)	0.9675	0.9321-1.000	100%	87.10%	79.30%	100%	88.90%
ARFI (m/s)
> F2 (1.22)	0.7701	0.6653-0.8749	78%	70%	85.50%	58.40%	74.10%
> F3 (1.48)	0.8669	0.7756-0.9583	82.60%	82.80%	83.90%	81.40%	82.70%
= F4 (1.77)	0.9188	0.8592-0.9784	100%	85.70%	77.50%	100%	87.70%
APRI
> F2 (0.75)	0.8107	0.7136-0.9077	75.60%	87.50%	93.20%	61.30%	81.50%
> F3 (0.75)	0.8272	0.7140-0.9405	87%	72.40%	77.40%	83.60%	76.50%
= F4 (1.46)	0.9143	0.8387-0.9899	81.80%	90%	80.10%	91%	88.90%
FIB-4
> F2 (1.47)	0.8652	0.7844-0.9461	78%	82.50%	91%	62.40%	80.20%
> F3 (2.0)	0.8703	0.7634-0.9773	82.60%	86.20%	86.70%	82%	85.20%
= F4 (3.91)	0.9636	0.9211-1.000	90.90%	95.70%	91.30%	95.50%	95.10%

AUC: Area under de curve; CI: Confidence interval; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.