Future of liver disease in the era of direct acting antivirals for the treatment of hepatitis C

doi:10.4254/wjh.v9.i7.352

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Mar 8, 2017; 9(7): 352-367
Published online Mar 8, 2017. doi: 10.4254/wjh.v9.i7.352

Table 4 Studies evaluating the effects of direct acting antivirals in liver transplant recipients

Ref.	HCV genotype	Fibrosis stage	Treatment	SVR12 rate	Observed improvement
Charlton et al[98], 2015	Cohort B	No cirrhosis: 111/229 (48.5%)	LDV/SOF + RBV 12 or 24 wk	No cirrhosis:	-
	G1a: 164/229 (71.6%)	Child A: 51/229 (22.3%)		12 wk 53/55 (96) 24 wk 55/56 (98)
	G1b: 63/229 (27.5%)	Child B: 52/229 (22.7%)		Child A:
	G4: 2/229 (0.9%)	Child C: 9/229 (3.9%)		12 wk 25/26 (96%)
		FCH: 6/229 (2.6%)		24 wk 24/25 (96%)
				Child B:
				12 wk 22/26 (85%)
				24 wk 23/26 (88%)
				Child C:
				12 wk 3/5 (60%)
				24 wk 3/4 (75%)
				FCH:
				12 and 24 wk 100%
Manns et al[101], 2016	Cohort B	No cirrhosis: 101/226 (44.7%)	LDV/SOF + RBV 12 or 24 wk	Genotype 1:	MELD improved in 58%
	G1a: 113/226 (50%)	Child A: 71/226 (31.4%)		No cirrhosis: 12 wk: 42/45 (93%)
	G1b: 86/226 (38%)	Child B: 40/226 (17.7%)		24 wk: 44/44 (100%)	Child B to A: 52%
	G4: 27/226 (12%)	Child C: 9/226 (4%)		Child A:	Child C to B: 60%
		FCH: 5/226 (2.2%)		12 wk: 30/30 (100%)
				24 wk: 27/28 (96%)
				Child B:
				12 wk: 19/20 (95%)
				24 wk: 20/20 (100%)
				Child C:
				12 wk: 1/2 (50%)
				24 wk: 4/5 (80%)
				FCH:
				12 and 24 wk: 100%

				Genotype 4:
				No cirrhosis:
				12 and 24 wk 100%
				Child A:
				12 wk 3/4 (75%)
				24 wk 100%
				Child B:
				12 and 24 wk 100%
				Child C:
				12 wk 0%
Poordad et al[100], 2016	G1a: 31/53 (58.5%)	F0: 6	DCV/SOF + RBV 12 and 24 wk	50/53 (94%)	-
	G1b: 10/53 (18.9%)	F1: 10
	G2: 0	F2: 7
	G3: 11/53 (20.7%)	F3: 13
	G4: 0	F4: 16
	G6: 1/53 (1.9%)	ND: 1
Brown et al[111], 2016	G1a: 87/151 (57.6%)	Cirrhosis: 97/151 (64.2%)	SMV/SOF ± RBV	133/151 (88%)	-
	G1b: 42/151 (27.8%)			SMV/SOF 105/119 (88%)
	G1 (unspecified): 22/151 (14.6%)			SMV/SOF + RBV 28/32 (88%)

LDV: Ledipasvir; SOF: Sofosbuvir; RBV: Ribavirin; DCV: Daclatasvir; SMV: Simeprevir; RVR: Rapid virological response (HCV-RNA < 15 UI after 4 wk of treatment); EVR: Early virological response (HCV-RNA < 15 UI after 12 wk of treatment); GRZ: Grazoprevir; ELB: Elbasvir; VEL: Velpatasvir; FCH: Fibrosing cholestatic hepatitis; HCV: Hepatitis C virus.

Citation: Ponziani FR, Mangiola F, Binda C, Zocco MA, Siciliano M, Grieco A, Rapaccini GL, Pompili M, Gasbarrini A. Future of liver disease in the era of direct acting antivirals for the treatment of hepatitis C. World J Hepatol 2017; 9(7): 352-367
URL: https://www.wjgnet.com/1948-5182/full/v9/i7/352.htm
DOI: https://dx.doi.org/10.4254/wjh.v9.i7.352