Thrombocytopenia in cirrhosis: Impact of fibrinogen on bleeding risk

Table 2 Comparison of baseline demographics according to baseline platelet count cut off value of 50 × 10⁹/L

	Platelet count < 50	Platelet count ≥ 50	P value
n	53 (21.5%)	193 (78.5%)
Age (yr)
Mean	51.23	53.37	0.13
SD	10	9.04
Median	52.38	55.26
Range	52	50
Gender
Female	40 (75.5%)	139 (72%)	0.62
Male	13 (24.5%)	54 (28%)
UKELD
Mean	54.16	52.72	0.09
SD	5.06	6.47
Diagnosis
ALD	10 (19%)	63 (33%)
Infectious	30 (56%)	52 (27%)
NASH	3 (6%)	7 (4%)
PSC	5 (9%)	29 (15%)
PBC	1 (2%)	8 (4%)
AIH	2 (4%)	5 (2%)
Wilsons	0	1 (0.5%)
Haemochromatosis	0	1 (0.5%)
Misc	2 (4%)	27 (14%)
Hb (g/L)
Mean	106.34	106.03	0.89
SD	15.08	16.94
Fibrinogen (g/L)
Mean	1.78	2.45	< 0.001
SD	0.62	1.15
Hep MA (mm)
Mean	35.28	47.85	< 0.001
SD	9.49	11.93
Total blood returned (mL)
Mean	1692.13	1831.6	0.69
SD	1426.72	2431.54
Median	1500	1110
Range	6305	21237

SD: Standard deviation; UKELD: United Kingdom end stage liver disease score; ALD: Alcoholic liver disease; NASH: Non-alcoholic steato-hepatitis; PSC: Primary sclerosing cholangitis; PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis; Hb: Haemoglobin; Hep MA: Maximum amplitude on heparinase thromboelastography.