Thrombocytopenia in cirrhosis: Impact of fibrinogen on bleeding risk

Table 1 Baseline demographics for patients with chronic liver disease who have undergone orthotopic liver transplantation¹

	Excessive transfusion	No excessive transfusion	Total	P value
n	114 (46.3%)	132 (53.7%)	246
Age (yr)
Mean	53.12	52.72	52.91	0.757
SD	9.68	10.38	10.04
Gender
Female	28 (24.6%)	39 (29.5%)	67 (27.2%)	0.381
Male	86 (75.4%)	93 (70.5%)	179 (72.8%)
UKELD
Mean	56.11	51.11	53.02	< 0.001
SD	10.55	5.08	6.22
Diagnosis
ALD	44 (38.6%)	29 (21.9%)	73 (29.6%)
Infectious	40 (35.1%)	42 (31.8%)	82 (33.3%)
NASH	4 (3.5%)	6 (4.5%)	10 (4.1%)
PSC	9 (7.9%)	25 (18.9%)	34 (13.8%)
PBC	3 (2.6%)	6 (4.5%)	9 (3.7%)
AIH	4 (3.5%)	3 (2.3%)	7 (2.8%)
Wilsons	1 (0.8%)	0 (0%)	1 (0.4%)
Haemochromatosis	1 (0.8%)	0 (0%)	1 (0.4%)
Misc	8 (7.0%)	21 (15.9%)	29 (11.8%)
Hb (g/L)
Mean	101.90	109.71	106.09	< 0.001
SD	16.89	15.38	16.53
Platelets (× 109/L)
Mean	83.18	107.29	96.12	0.005
SD	55.03	75.14	67.53
Median	67	84.5	76.0
IQR	42.5	77.5	61.25
Fibrinogen (g/L)
Mean	1.96	2.60	2.3	0.004
SD	0.91	1.15	1.09
Hep MA (mm)
Mean	42.15	47.71	45.14	0.001
SD	12.68	11.87	12.54
Total blood returned (mL)
Mean	3323	487	1802
SD	2536	419	2251

¹Excessive transfusion defined as blood volume returned > 1200 mL. SD: Standard deviation; UKELD: United Kingdom end stage liver disease score; ALD: Alcoholic liver disease; NASH: Non-alcoholic steato-hepatitis; PSC: Primary sclerosing cholangitis; PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis; Hb: Haemoglobin; Hep MA: Maximum amplitude on heparinase thromboelastography.