Fibrosis assessment using FibroMeter combined to first generation tests in hepatitis C

Table 3 Performance of aspartate transaminase to platelet ratio index, Forns, FibroMeter^Virus3G and combination algorithm to discriminate significant fibrosis (F0-F1 vs F2-F4) in derivation and validation population

Serum fibrosis tests	AUROC (95%CI)	Cut-off value	Se (%)	Sp (%)	PPV (%)	NPV (%)	OA (%)
Derivation population (n = 222)
FM score	0.855 (0.801-0.898)	0.61	79	81	85	74	80
APRI	0.815 (0.757-0.864)	0.51	87	53	71	76	72
		1.52	35	98	96	53	62
Forns	0.769 (0.708-0.823)	4.23	94	31	64	79	66
		6.94	41	87	81	53	61
Apri + FM			76	82	85	72	79
Forns + FM			81	75	81	75	78
Validation population (n = 538)
FM score	0.854 (0.821-0.888)	0.61	67	87	89	63	75
Apri + FM			57	88	87	57	69

¹APRI ≤ 0.5 exclude significant fibrosis;

²APRI > 1.5 predict significant fibrosis;

³Forns ≤ 4.2 exclude significant fibrosis;

⁴Forns > 6.9 predict significant fibrosis. FM: FibroMeterVirus3G; AUROC: Area under ROC curve; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; OA: Overall accuracy; APRI: Aspartate transaminase to platelet ratio index.