Efficacy and safety of telaprevir- and simeprevir-based triple therapies for older patients with chronic hepatitis C

Table 1 Patient characteristics by age (telaprevir)

Factors (median, range)	Patients aged < 66	Patients aged ≥ 66	P value
n	78	34
Gender, n (male/female)	41/37	20/14	0.68
Age (yr)	56 (28-65)	69 (66-81)	< 0.001
Body weight (kg)	61.1 (35.0-97.4)	57.8 (41.0-74.8)	0.105
Body mass index (kg/m2)	22.7 (15.8-32.2)	22.9 (17.9-28.9)	0.892
Baseline HCV-RNA (log IU/mL)	6.7 (3.9-7.7)	6.7 (3.1-7.8)	0.766
White blood cell (/mm3)	5000 (1900-8720)	4500 (2700-7700)	0.245
Hemoglobin (g/dL)	14.0 (9.1-18.6)	13.5 (9.5-16.3)	0.121
Platelets (× 104/mm3)	15.8 (6.5-28.7)	13.4 (8.3-29.0)	0.068
Albumin (mg/dL)	4.1 (2.7-5.9)	3.9 (2.4-4.4)	0.007
AST (IU/L)	40 (17-249)	45 (20-163)	0.909
ALT (IU/L)	48 (15-278)	38 (15-189)	0.486
γ-GTP (IU/L)	39 (11-717)	25 (11-144)	0.034
Serum creatinine (mg/dL)	0.7 (0.4-1.2)	0.8 (0.4-1.0)	0.036
Estimated GFR (mL/min)	79.0 (44.0-134.0)	71.5 (39.0-101.9)	0.006
Prior treatment response, n (naïve/relapse/non-responder)	45/26/7	15/15/4	0.403
Liver histology (F0-2/3-4/ND)	21/6/51	4/3/27	0.348
IL28B SNP (rs8099917), n (TT/non-TT/ND)	51/22/5	28/5/1	0.235
HCV ISDR, n (0/1-3 /4-/NT)	32/26/6/14	15/10/2/7	0.955
HCV Core 70, n (Wild/Mutant/ND)	46/18/14	18/10/6	0.751
HCV Core 91, n (Wild/Mutant/ND)	42/22/14	19/9/6	1
Serum CXCL10 (pg/mL)	510 (95-1794)	543 (118-1218)	0.445

GFR: Glomerular filtration rate; IL28B SNP: Interleukin-28B single nucleotide polymorphism; ND: Not determined; ISDR: Interferon sensitivity-determining region; HCV Core 70 or 91: At position 70 or 91 of the HCV core protein; CXCL10: Chemokine (C-X-C motif) ligand 10; HCV: Hepatitis C virus; AST: Aspartate transaminase; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyl-transpeptidase.