Primary biliary cholangitis metachronously complicated with combined hepatocellular carcinoma-cholangiocellular carcinoma and hepatocellular carcinoma

Figure 2 Immunohistochemistry findings for the initial tumor. A: HCC component stained positive for hepatocyte; B: HCC component stained positive for CK18; C: Both HCC and CCC components stained negative for alpha fetoprotein; D: CCC component stained positive for CK7; E: CCC component stained positive for CK19; F: Epithelial cell adhesion molecule stained positive for the HCC component and weakly positive for the CCC component. CCC: Cholangiocellular carcinoma; CK: Cytokeratin; HCC: Hepatocellular carcinoma.