Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

Table 3 Safety profile

	Total (n = 246)	< 75 yr (n = 167)	≥ 75 yr (n = 79)
Common adverse effects
Headache	6 (2.4)	4 (2.4)	2 (2.5)
Pruritus	2 (0.8)	0	2 (2.5)
Constipation	2 (0.8)	2 (1.2)	0
Stomatitis	2 (0.8)	2 (1.2)	0
Skin eruption	1 (0.4)	1 (0.6)	0
Chill	1 (0.4)	1 (0.6)	0
Nausea	1 (0.4)	1 (0.6)	0
Fever	1 (0.4)	1 (0.6)	0
Insomnia	1 (0.4)	1 (0.6)	0
Hematological abnormalities
Hemoglobin < 10.0 g/dL	0	0	0
Platelet count < 50 × 109/L	0	0	0
Laboratory abnormalities
Total bilirubin > 3.0 mg/dL	0	0	0
Alanine aminotransferase > 5 × ULN	0	0	0
Serum creatinine > 1.5 × baseline	0	0	0
Death	0	0	0
Discontinuation due to adverse effects	2 (0.8)	2 (1.2)	0
Cerebral hemorrhage	1 (0.4)	1 (0.6)	0
Skin eruption	1 (0.4)	1 (0.6)	0

Data are expressed as n (%).