Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma

Table 5 Univariate (Fisher’s exact test) and multivariate (binomial logistic regression) analysis of factors associated with the achievement of disease control in patients with Barcelona Clinic Liver Cancer C hepatocellular carcinoma

Variable	DC (43)	No DC (67)	Univariate analysis	Multivariate analysis
			P value	Odds ratio (95%CI)	P value
Age
< 65 yr	15	27	0.229	-
≥ 65 yr	28	40
Gender
Male	35	56	0.471	-
Female	8	11
PS
0	37	60	0.06	-
1/2	6	7
Diabetes
No	34	53	0.653	-
Yes	9	14
Child-Pugh score
A	31	51	0.524	-
B	12	16
N nodules
Single	13	22	0.078
2-3	11	9		-
Multinodular/infiltrating	19	36
Tumor size
≤ 5 cm	30	26	0.0061	1	0.298
> 5 cm	13	41		0.617 (0.236-1.610)
Macrovascular invasion
No	32	28	0.00031	-	-
Yes	11	39
Extrahepatic spread
No	40	51	0.021	-	-
Yes	3	16
Macrovascular invasion and/or extrahepatic spread
No	29	20	< 0.00011	1	0.0021
Yes	14	47		0.263 (0.111-0.622)
AFP
≤ 200 ng/mL	35	39	0.0081	1	0.179
> 200 ng/mL	8	28		0.461 (0.169-1.258)
NIACE score
≤ 3	34	50	0.502	-
> 3	9	17
Treatment after BCLC C diagnosis
No	4	18	0.041	1	0.270
Yes	39	49		0.531 (0.147-1.917)

¹Statistically significant results. PS: Performance status; AFP: Alpha-fetoprotein; DC: Disease control.