Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma

Table 3 Multivariate Cox regression model including alphafetoprotein and disease control as time dependent covariates

Variable	Multivariate analysis
	Hazard ratio (95%CI)	P value
Macrovascular invasion
No	1	0.917
Yes	1.066 (0.412-2.762)
Macrovascular invasion and/or extrahepatic spread
No	1	0.366
Yes	1.552 (0.584-4.124)
Tumor size
≤ 5 cm	1	0.266
> 5 cm	1.369 (0.786-2.382)
AFP (> 200 ng/mL vs ≤ 200 ng/mL)
< 6 mo	5.073 (2.159-11.916)	0.00021
7-12 mo	0.948 (0.275-3.267)	0.932
> 12 mo	1.698 (0.620-4.648)	0.303
DC (Yes vs No)
< 6 mo	0.220 (0.075-0.650)	0.096
7-12 mo	0.463 (0.181-1.189)	0.109
> 12 mo	0.110 (0.038-0.314)	< 0.00011

For all other variables single hazard ratios were reported.

¹Statistically significant results. AFP: Alphafetoprotein; DC: Disease control.