Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma

Table 2 Univariate (Kaplan-Meier) and multivariate (Cox proportional hazard regression) survival analysis of patients with Barcelona Clinic Liver Cancer C hepatocellular carcinoma according to clinical and tumor variables

Variable	Univariate analysis		Multivariate analysis
	Survival time (mo)	P value	Hazard ratio (95%CI)	P value
Age
< 65 yr	13.9	0.903	-	-
≥ 65 yr	13.8
Gender
Male	13	0.900	-	-
Female	14.2
PS
0	10.3	0.128	-	-
1/2	13.9
Diabetes
No	13	0.813	-	-
Yes	13.8
Child-Pugh score
A	13.4	0.957	-	-
B	12.8
N nodules
Single	13.8	0.776	-	-
2-3	13.4
Multinodular/infiltrating	13
Tumor size
≤ 5 cm	13.9	0.0221	1	0.275
> 5 cm	9.9		1.357 (0.784-2.349)
Macrovascular invasion
No	15.8	0.0141	1	0.866
Yes	9.5		1.095 (0.379-3.162)
Extrahepatic spread
No	11.2	0.274	-	-
Yes	6.7
Macrovascular invasion and/or extrahepatic spread
No	13.8	0.0081	1	0.429
Yes	6.3		1.547 (0.523-4.571)
AFP
≤ 200 ng/mL	15.8	0.00021	1	0.0061
> 200 ng/mL	6.3		2.194 (1.249-3.855)
DC
No	7.6	< 0.00011	1	< 0.00011
Yes	15.8		0.190 (0.098-0.367)
NIACE score
≤ 3	13.8	0.515	-	-
> 3	6.7

¹Statistically significant results. PS: Performance status; AFP: Alpha-fetoprotein; DC: Disease control.