Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma

Table 3 Uni- and multi-variate analyses for disease-free survival after hepatic resection

Characteristic	n	Univariate analysis		Multivariate analysis
		HR (95%CI)	P-value	HR (95%CI)	P-value
Age			0.316		0.1007
≤ 69	39	1		1
> 69	39	0.74 (0.40-1.33)		0.58 (0.30-1.11)
Gender			0.4847		0.298
Female	17	1		1
Male	61	0.78 (0.41-1.60)		0.66 (0.31-1.41)
Occult HBV infection			0.8739		0.7096
Absent	51	1		1
Present	27	1.05 (0.55-1.93)		1.13 (0.59-2.17)
Alcohol abuse			0.2752
Absent	59	1
Present	19	0.66 (0.28-1.35)
Diabetes mellitus			0.8853
Absent	51	1
Present	27	0.95 (0.49-1.78)
NASH			0.6226
Absent	70	1
Present	8	1.25 (0.47-2.75)
Obesity			0.7641
Absent	54	1
Present	24	1.10 (0.57-2.02)
Fibrosis			0.1477		0.2273
F0-2	44	1		1
F3, 4	34	1.54 (0.86-2.80)		1.54 (0.78-2.81)
Vp			0.0013		0.0217
Absent	47	1		1
Present	31	2.90 (1.53-5.50)		2.52 (1.15-5.50)
T12/T34			0.0006		0.4074
T12	38	1		1
T34	40	3.14 (1.62-6.43)		1.57 (0.53-4.67)
Solitary/multiple			0.0002		0.0499
Solitary	47	1		1
Multiple	31	3.23 (1.73-6.14)		2.32 (0.99-5.42)

HR: Hazard ratio; CI: Confidence interval; Vp: Portal vein invasion; NASH: Non-alcoholic steatohepatitis; HBV: Hepatitis B virus.