Liver decompensation predicts ribavirin overexposure in hepatitis C virus patients treated with direct-acting antivirals

Table 3 Baseline predictors of average plasmatic Ribavirin levels in the first 8 wk of therapy

	Univariate analysis			Multivariate analysis
	β value	95%CI	P value	β value	95%CI	P value
Baseline ribavirin dosage (mg/kg)	205	77; 332	0.002	161	36; 286	0.013
IFN-experienced	97	-303; 497	0.6
Male gender	-539	-975; -103	0.016	-349	-765; 68	0.099
Age (yr)	13	-9; 34	0.3
White race	424	-714; 1563	0.5
Bilirubin (mg/L)	870	-920; 2670	3
Creatinine (mg/L)	-2890	-16830; 11040	7
Child-Pugh class	232	66; 399	0.007	192	35; 348	0.017
Liver stiffness (kPa)	-1.6	-14; 11	0.8
HIV infection	76	-314; 466	0.7

IFN: Interferon; HIV: Human immunodeficiency virus.