Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury

Table 1 Patient demographics

Patient (gender/age)	Diagnosis	Resection performed	Preoperative chemotherapy	Peak AST, μkat/L	Peak ALT, μkat/L	Day of enzyme peak (AST, ALT), (d)	Peak bilirubin, μmol/L, (d)	Fibrosis (stage)	Inflam-mation	Steatosis
P1 (M/75)	mCRC	Atypical resection	Yes	4.39	2.23	1	24 (1)	1	0	1
P2 (F/71)	mCRC	Multiple resections	Yes	23.05	21.93	2	53 (1)	1	0	2
P3 (M/39)	Inflammatory pseudotumor	Extended right hepatectomy	No	4.19	4.81	1	41 (1)	-	-	1
P4 (M/75)	Malignant melanoma metastasis	Multiple atypical resections	Yes	2.32	1.90	1	12 (2)	1	0	1
P5 (M/63)	mCRC	Bisegmentectomy	Yes	6.25	7.03	2	16 (1)	1	0	1
P6 (F/78)	Carcinoid metastasis	Left hepatectomy	No	3.73	2.89	1	20 (1)	1	0	1
P7 (F/61)	mCRC	Right hepatectomy	Yes	7.14	6.11	1	14 (1)	1	0	0
P8 (M/55)	Malignant melanoma metastasis	Right hepatectomy	No	7.90	8.84	2	48 (2)	0	0	2
P9 (M/68)	mCRC	Right hepatectomy + atypical resection	Yes	3.85	1.91	1	82 (8)	3-4	2	1
P10 (M/37)	mCRC	Right hepatectomy	Yes	6.71	3.96	2	33 (2)	1	0	0
P11 (M/58)	mCRC	Right hepatectomy + atypical resection	Yes	11.16	9.28	1	53 (2)	1	0	3

Steatosis was defined as 1: Mild (< 33%); 2: Moderate (33%-66%); 3: Severe (> 66%). Fibrosis was defined as Stage 1: Portal fibrosis; Stage 2: Periportal fibrosis; Stage 3: Septal fibrosis; and Stage 4: Cirrhosis. mCRC: Metastatic colorectal cancer.