Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis

Figure 2 Macroscopic images of pig livers following interruption of portal blood flow and structural comparison of pig and human liver lobules. A: Liver removed from a pig at week 2 after PTPE. Segmental macroscopic atrophy could be seen (arrowheads); B: Portal thrombosis was observed at the cut surface (arrow) in the embolized area (*), and fibrous thickening of the portal areas was observed (arrowheads) compared with nonembolized area (†). A clear border (dotted line) was observed between these areas; C-F: Microscopic views (C, D: Pig; E, F: Human) show central veins (CV) and portal areas (P) in HE-stained sections (C, E), but these features are more clearly observed in silver-stained sections (D, F). Lobule structure was less well defined in human specimens (F).