Copyright
©The Author(s) 2017.
World J Hepatol. Nov 18, 2017; 9(32): 1210-1226
Published online Nov 18, 2017. doi: 10.4254/wjh.v9.i32.1210
Published online Nov 18, 2017. doi: 10.4254/wjh.v9.i32.1210
Figure 3 Schematic diagram illustrating the mechanism of modification of pregnane X receptor activity and function after SUMOYLATION.
A: SUMO1 binding to PXR has been shown to increase its transcriptional activity; B: Sumo (3) ylation of PXR causes a shift from the canonical transcriptional function of PXR towards the transcriptional repression of NF-κB. NF-κB: Nuclear factor kappa B; PXR: Pregnane X receptor; RXR: Retinoid X receptor.
- Citation: Mohandas S, Vairappan B. Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases. World J Hepatol 2017; 9(32): 1210-1226
- URL: https://www.wjgnet.com/1948-5182/full/v9/i32/1210.htm
- DOI: https://dx.doi.org/10.4254/wjh.v9.i32.1210