Biliary complications following liver transplantation: Single-center experience over three decades and recent risk factors

Table 5 Univariable and multivariable analyses for identification of risk factors for anastomotic biliary complications since 2006

	Variable	Univariable analysis		Multivariable analysis
		P-value	OR (95%CI)	P-value	OR (95%CI)
Recipient data	MELD	0.029	1.036 (1.003-1.050)	0.006	1.035 (1.010-1.060)
	BMI	0.438
	Days on the waiting list	0.594
	Gender	0.494
	Age	0.752
	ICU stay in days	0.025	1.018 (1.001-1.012)	0.093
	Pre-transplant PVT	0.056
	Creatinine	0.042	1.003 (1.001-1.005)
	Bilirubine	0.034	1.001 (1.001-1.002)
	Indication HCC	0.328
	Indication PSC	0.415
	Indication ALF	0.620
	Indication HCV cirrh.	0.685
	Indication alc. cirrh.	0.769
	Indication biliary dis.	0.115
Transplant-specific data	Gender mismatch	0.620
	Cold ischemic time	0.417
	Era of transplantation	0.124
	Preservation solution	0.746
	> 1 arterial anastom.	0.396
	Aortal anastomosis	0.331
	Portal vein interpos. Graft	0.251
	Hepaticojejunostomy	0.425
	Post-transplant HAT	0.048	2.999 (1.010-8.056)	0.019	3.543 (1.283-10.178)
	Operative duration	0.624
Donor-specific data	Age	0.738
	Gender male	0.003	1.835 (1.050-3.303)	0.066
	BMI	0.014	0.923 (0.861-0.990)	0.056
	Pre-transplant ICU stay	0.115
	Body temperature	0.921
	Bilirubine	0.022	1.027 (1.005-1.050)	0.073
	Creatinine	0.020	1.003 (1.001-1.005)	0.010	1.003 (1.001-1.006)
	CRP	0.406
	ALT	0.765
	AST	0.613
	GGT	0.278
	Urea	0.581
	CMV positivity	0.100

MELD: Model of End-Stage Liver Disease; BMI: Body mass index; ICU: Intensive care unit; ALT: Alanine aminotransferase; AST: Aspartate transaminase; GGT: Gamma glutamyltransferase; CMV: Cytomegalovirus; PVT: Portal vein thromboses; HCC: Hepatocellular carcinoma; PSC: Primary sclerosing cholangitis; ALF: Acute liver failure; HCV: Hepatitis C virus; CRP: C-reactive protein.