Cockcroft-Gault revisited: New de-liver-ance on recommendations for use in cirrhosis

Table 1 Different methods of estimating creatinine-clearance (A): Equations I-IV were evaluated in the original Cockcroft-Gault study, Equation V is a modified Cockcroft-Gault that only incorporates age and serum creatinine into the equation; B: Different body weight equations tested in the Cockcroft-Gault equation to compensate for various body types

A: Formula = CrCl (mL/min)		B: Formula = weight (kg)
I1	[(140 - age)(weight in kg)] (72 × SCr)	IBWmale	50 + (2.3 kg × inches > 60)
II	(100/SCr) - 12	IBWfemale	45.5 + (2.3 kg × inches > 60)
III	98 - 16 × [(age - 20)/20] SCr	AdjBW	IBW + [(TBW - IBW) × C2]
IV	(94.3/SCr) - 1.8	LBWmale	9270 × TBW 6680 + (216 × BMI)
V	(140 - age) SCr	LBWfemale	9270 × TBW
VI	100 SCr	FFW	Calculated using BIA[15]

¹CrCl × (1.73 m²/BSA) to normalize to body surface area (BSA) of 1.73 m²;

²0.3 for 30% ABW and 0.4 for 40% ABW. AdjBW: Adjusted body weight; BMI: Body mass index; CrCl: Creatinine clearance; FFW: Fat free weight; IBW: Ideal body weight; LBW: Lean body weight; SCr: Serum creatinine; TBW: Total body weight; BIA: Bioelectrical impedance analysis.