T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection

Figure 3 Representative plots showing CD4⁺CD8^low T lymphocyte activation in terms of cytokine production. Production of IL-4 and/or IFNγ was analyzed after exposure of the cells to the glutathione S-transferase T1 peptides. As an example, patient 3 had 78.85% of the double positive cells activated with pool 3 and 2.9% with pool 6. Patient 4 had 6.05% of cells activated with pool 3, whereas pool 5 did not have any effect. Patient 17 showed 21.21% of cell activation with pool 3, but no response was observed when the cells were cultured with pool 2. In all the cases, the cells produced both cytokines, indicating a Th0 type of response.